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可见的肝脏损伤出现前,及早确定嗜酒过度是临床实践中的一个普遍问题。血清r-谷氨酰转肽酶(GGT)在诊断肝脏疾病中广为应用,但其特异性较低,即异常增高的GGT 并不一定意味着肝脏发生结构病变。不过,对于缺少肝病史者,GGT 的增高可认为是嗜酒过度的报警信号。作者试图模拟大量饮酒后,无肝病而GGT 升高的“适度饮酒者”体内发生的变化。所谓的“适度”被限定为每日饮用任何形式的相当于60—80g 的乙醇。通过检测试者血清碱性磷酸酶、谷丙转氨酶、谷草转氨酶、胆红素、胆碱脂酶、亮氨酸氨肽酶、GGT 和LDH 及其同工酶水平的变化,来确认饮酒是否适度。有人证明仅此一次性试验对鉴定隐性酒精中毒尚缺乏灵敏性。
It is a common problem in clinical practice to identify alcohol abuse before visible liver damage occurs. Serum glutamyl transpeptidase (GGT) is widely used in the diagnosis of liver disease, but its low specificity, ie abnormally elevated GGT, does not necessarily mean that the liver is structurally diseased. However, for those with a history of liver disease, an increase in GGT may be considered an alarm of excessive alcohol consumption. The authors attempted to model in vivo changes in “moderate drinkers” with a high GGT without liver disease after heavy drinking. The so-called “moderation” is defined as drinking any form of ethanol equivalent to 60-80 g daily. To determine whether drinking alcohol is appropriate by measuring serum levels of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin, cholinesterase, leucine aminopeptidase, GGT and LDH and their isoenzymes . It has been shown that this one-off test is not sensitive to the identification of tactile alcoholism.