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目的 探讨水飞蓟素 (ＳＢ)、银杏叶黄酮 (ＧＢ)、葡多酚(ＧＰ)、大豆异黄酮 (ＳＩ) 4种类黄酮经口给药 (ｉｇ)对抗肿瘤药顺铂 (ＣＤＤＰ)所致的肾损害效应。方法 给大鼠 1次腹腔内注射 (ｉｐ)ＣＤＤＰ 5ｍｇ ｋｇ ,给予动物ＣＤＤＰ前 1ｈ ,ｉｇ剂量为 12 0～ 480ｍｇ ｋｇ类
Objective To investigate the effects of oral administration of four kinds of flavonoids, including silymarin (SB), ginkgo biloba flavone (GB), grape polyphenol (GP) and soy isoflavone (SI) on renal damage caused by anticancer drug cisplatin (CDDP) effect. Methods One dose of 5 mg of CDDP was intraperitoneally injected into rats and the first dose of CDDP was given to animals for 12 h to 480 mg kg