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目的:了解白细胞介素-6(interleukin-6,IL-6)基因启动子区域单核苷酸多态位点-634C/G与青岛地区汉族人群过敏性哮喘的相关性。方法:采用聚合酶链反应-限制性片段长度多态性分析方法对青岛地区479例健康个体和481例过敏性哮喘患者IL-6基因启动子-634C/G多态性进行观察。结果:过敏性哮喘组与健康对照组CC、CG和GG基因型以及C和G等位基因频率分布均无统计学差异,携带GG、CG、CC基因型个体哮喘患病风险依次递增。结论:IL-6基因启动子-634C/G位点多态性与青岛地区人群过敏性哮喘发生无相关性,但携带CC等位基因型的个体过敏性哮喘的发病风险可能增加。
Objective: To investigate the association between -634C / G SNP in the promoter region of interleukin-6 (IL-6) gene and allergic asthma in Han population of Qingdao. Methods: The polymorphism of IL-6 gene promoter -344C / G in 479 healthy individuals and 481 allergic asthmatics in Qingdao area was observed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: There was no significant difference in genotype frequency of CC, CG, GG and allele frequencies of C and G between allergic asthma group and healthy control group. The risk of asthma in individuals with GG, CG and CC genotypes increased successively. CONCLUSION: There is no correlation between IL-6 gene promoter -634C / G polymorphism and allergic asthma in Qingdao population. However, the risk of allergic asthma may be increased in individuals with CC allele.