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意大利是慢性病毒性肝炎发病率高和耗酒量最大的国家之一,为评估两者和其他病因因素在该国肝硬化和肝细胞癌(HCC)发生中所起作用,作者进行了此项前瞻性多中心研究。 病例和方法:收集覆盖全意大利的21个医疗中心1992年7月～12月确诊的肝硬化共1829例,其中伴HCC者217例(均经病理证实)。肝硬化的病因分类及标准是:血清HBsAg
Italy is one of the countries with the highest incidence and consumption of chronic viral hepatitis. To assess the role of both and other etiologic factors in the development of cirrhosis and hepatocellular carcinoma (HCC) in the country, the authors conducted this prospective Multi-center study. Case and Methodology: A total of 1829 cirrhosis cases were confirmed in 21 medical centers covering all of Italy from July 1992 to December 1992, including 217 with HCC (pathologically confirmed). The cause of cirrhosis classification and criteria are: serum HBsAg