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目的针对给药间隔因素分别对临床进行干预,观察药品不良反应发生率的变化,旨在提高门诊抗菌药物注射剂的用药安全性。方法采用前瞻性随机对照方法 ,选取天津市第一中心医院2007年1月—2007年12月的门诊中使用抗菌药物注射剂的患者为研究对象,随机分为对照组和干预组,采用培训教育、资料整理和发放、行政监督等干预措施,针对给药间隔因素进行干预并分析。结果与对照组相比,干预组给药间隔明显更加合理(P<0.01),干预后不良反应的发生率明显降低(P<0.01)。结论对给药间隔的干预效果明显,不良反应发生率大大降低,对该因素干预有效。
Objective To intervene separately according to the interval of administration and observe the change of incidence of adverse reactions of drugs to improve the medication safety of outpatient antibacterial injection. Methods A prospective randomized controlled trial was conducted in the first Central Hospital of Tianjin from January 2007 to December 2007. The patients were randomly divided into control group and intervention group. Training, education, Data collation and payment, administrative supervision and other interventions, intervention interval factors for intervention and analysis. Results Compared with the control group, the intervention interval in the intervention group was significantly more reasonable (P <0.01), and the incidence of adverse reactions was significantly lower after intervention (P <0.01). Conclusion The effect of intervention on the administration interval is obvious, the incidence of adverse reactions is greatly reduced, and the intervention of this factor is effective.