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目的 :观察牛磺酸 (Tau)对肾血管性高血压大鼠心肌血管紧张素Ⅱ (AngⅡ )及胶原含量的影响 ,并探讨左室肥厚的机制。方法 :建立二肾一夹 ( 2K1C)肾血管性高血压大鼠模型。应用放免法测定AngⅡ (MAC) ,羟脯氨酸法测定大鼠心肌胶原含量 (MCC)。显微镜下观察心肌组织结构改变 ,测微计测量心肌纤维直径 (MFD) ,并对MCC及MFD与MAC进行线性相关分析。结果 :2K1C肾性高血压大鼠MCC及MFD与MAC含量较假手术组 (Sham组 )显著增加 (P <0 .0 1 )。MCC及MFD与MAC显著正相关 (r =0 .83 2 3 ,0 .83 51 3 ,P <0 .0 1 )。牛磺酸可显著降低 2K1C大鼠尾动脉收缩压 (SBP)、MFD、MAC、MCC和左心室 /体重比值 (LVW /BW) ,并抑制心肌细胞肥大及心肌间质的增生。结论 :2K1C大鼠心肌肥厚与心肌局部AngⅡ增加有关 ;牛磺酸可能通过降低心肌AngⅡ含量而逆转肾性高血压左室肥厚。
Objective: To observe the effect of taurine on myocardial angiotensin Ⅱ (Ang Ⅱ) and collagen content in renovascular hypertensive rats and to explore the mechanism of left ventricular hypertrophy. Methods: To establish a 2K1C model of renal vascular hypertension in rats. Ang Ⅱ (MAC) was measured by radioimmunoassay and myocardial collagen content (MCC) was measured by hydroxyproline. Myocardial tissue structure was observed under a microscope. Myocardial fiber diameter (MFD) was measured by micrometer, and linear correlation analysis was performed between MCC, MFD and MAC. Results: The MCC, MFD and MAC contents of 2K1C hypertensive rats were significantly increased compared with sham operation group (Sham group) (P <0.01). MCC and MFD had a significant positive correlation with MAC (r = 0.83 2 3, 0.83 51 3, P <0.01). Taurine significantly reduced tail artery systolic blood pressure (SBP), MFD, MAC, MCC and LVW / BW in 2K1C rats and inhibited cardiomyocyte hypertrophy and myocardial interstitial hyperplasia. CONCLUSION: Myocardial hypertrophy in 2K1C rats is associated with an increase in myocardial AngⅡ. Taurine may reverse left ventricular hypertrophy in renal hypertension by decreasing myocardial AngⅡ.