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目的制备不同孔体积微丸,并考察其物理特性和压缩特性。方法不同体积比的乙醇-水作黏合剂,采用挤出-滚圆工艺制备具有不同孔体积的微丸,并测定微丸的物理性质,采用压缩度和抗张强度-压力曲线表征微丸的压缩特性。结果以3种比例乙醇-水溶液做黏合剂,采用挤出-滚圆法制备不同孔体积微丸,且微丸流动性良好,随着黏合剂中乙醇用量增加,微丸内孔体积增加,抗张强度减小;高孔体积微晶纤维素微丸可压缩性较低孔体积微丸好,3种孔体积的磷酸二氢钙-微晶纤维素(4∶1)微丸可压缩性均较好,且三者没有明显差异,3种孔体积的乳糖-微晶纤维素(4∶1)微丸可压缩性也较好,且差异也不明显。结论所制备的高孔体积微晶纤维素、3种孔体积磷酸二氢钙-微晶纤维素(4∶1)微丸、3种孔体积乳糖-微晶纤维素(4∶1)微丸可压性较好,为多单元片剂的制备提供科学参考。
Objective To prepare different pore volume pellets and investigate their physical properties and compression properties. Methods Pellets with different pore volume were prepared by extrusion-spheronization process with different volumes of ethanol-water as binder. The pellets were measured for their physical properties. The compression and tensile strength-pressure curves were used to characterize the compression of pellets characteristic. Results Three different proportions of ethanol-water solution were used as binders, and different pore volume pellets were prepared by extrusion-spheronization. The pellets had good fluidity. With the increase of ethanol content in the adhesive, the pore volume of the pellets increased, The strength of the microporous cellulose microcapsules with high pore volume is lower than that of the microporous ones with the lowest compressibility. The compressibility of three kinds of microporous calcium phosphate monobasic microcrystalline cellulose (4:1) Good, and there is no significant difference among the three, the compressibility of lactose-microcrystalline cellulose (4: 1) pellets of three pore volumes is also better, and the difference is not obvious. Conclusions The prepared high-volume-volume microcrystalline cellulose, three kinds of pore-size monocalcium phosphate-microcrystalline cellulose (4:1) pellets, three kinds of porous lactose-microcrystalline cellulose Compressibility is better, for the preparation of multi-unit tablets provide a scientific reference.