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许多研究表明,巨噬细胞激活因子(MAF)能增强巨噬细胞杀伤微生物和杀伤肿瘤的活性;细胞免疫的发生是与对最初感染微生物的全身迟发型变态反应(DTH)有关。作者是在鼠与原发感染或特异预防接种完全无关的一种限定状态(即鼠发生DTH和给鼠转注淋巴因子的状态)下,观察鼠对鼠伤寒沙门氏菌感染的抵抗力。给7周龄的C57BL/6鼠皮下注射1mg牛血清白蛋白(BSA,含于0.2ml福氏佐剂
Numerous studies have shown that macrophage activating factor (MAF) enhances macrophage-killing and tumor-killing activity; cellular immunity is associated with systemic delayed-onset allergy (DTH) to initially infected microorganisms. The authors observed the resistance of mice to Salmonella typhimurium infection in a defined condition (ie, the condition in which the mouse develops DTH and the donor is infused with lymphokines) independently of the primary infection or specific vaccination. Seven-week-old C57BL / 6 mice were injected subcutaneously with 1 mg bovine serum albumin (BSA in 0.2 ml Freund’s adjuvant