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现在认为Ph~1阳性慢性粒细胞型白血病(慢粒),是多能干细胞的克隆性疾病,后者可能是粒细胞系和淋巴细胞系的共同前身。利用新的细胞标志技术如抗急性淋巴细胞型白血病(急淋)血清、末端脱氧核苷酸转移酶(TdT)等,已进一步描述了慢粒急变时的细胞特征,并能将它们与其他白血病(尤其急淋)的幼雅细胞比较,现已发现有些急淋病例的幼稚细胞Ph~1阳性而无慢粒的其他表现。慢粒急变时的幼稚细胞有粒细胞特征者比有淋巴细胞特征者为多,而表现为Ph~1阳性急性白血病者则相反。现在已发现在Ph~1阳性急淋、慢粒的淋巴母细胞型急变之间于形态、细胞
Now that Ph ~ 1-positive chronic myelogenous leukemia (CML) is a clonal disease of pluripotent stem cells, the latter may be common precursor of granulocyte and lymphocyte lines. The use of novel cell-marker technologies such as anti-acute lymphoblastic leukemia (AML) serum, terminal deoxynucleotidyl transferase (TdT), etc., have further described the cellular features of chronic myxomatosis and their association with other leukemias (Especially acute lymphocytic leukemia cells), it has been found that some acute cases of naive cells Ph ~ 1 positive without other manifestations of CML. The naive cells with blast crisis have more granulocytes than those with lymphocytes, whereas those with Ph ~ 1 positive acute leukemia show the opposite. It has now been found in the Ph ~ 1 positive acute leaching, chronic granulocyte-type blast crisis in morphology, cells