Calpain-2 activity promotes aberrant endoplasmic reticulum stress-related apoptosis in hepatocytes

• 作 者: Ru-Jia Xie Xiao-Xia Hu Lu Zhen
• 机 构: GuizhouProvincialKeyLaboratoryofPathogenesisandDrugResearchonCommonChronicDiseases,DepartmentofPatho
• 出 处: 世界胃肠病学杂志:英文版
• 发表日期: 2020年13期
• 关键词: Calcium Calpain-2 Caspase-12 Endoplasmic reticulum stress APOPTOSIS HEPATOCYTE
• 基金项目: the National Natural Science Foundation of China,No.81560105,the Department of Science and Technology of Guizhou Province,No.LH(2014)7074

BACKGROUND Calpain-2 is a Ca^2+-dependent cysteine protease,and high calpain-2 activity can enhance apoptosis mediated by multiple triggers.AIM To investigate whether calpain-2 can modulate aberrant endoplasmic reticulum(ER)stress-related apoptosis in rat