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目的探讨奥美拉唑治疗消化性溃疡的临床疗效。方法选择2008-03-2010-07在山东省垦利县人民医院治疗的60例消化性溃疡患者,随机分为两组,治疗组和对照组各30例,两组均应用阿莫西林胶囊500 mg,3次/d,治疗组在此基础上给予奥美拉唑20 mg,早晚各服一次;对照组应用雷尼替丁150 mg,早晚各服一次。比较两组疗效和不良反应。结果治疗组溃疡愈合率为93.3%,总有效率为100%;对照组溃疡愈合率为70.0%,总有效率为86.7%。两组比较有统计学意义(P<0.01);两组治疗期间均未出现明显的不良反应,用药安全。结论奥美拉唑治疗消化性溃疡效果显著,不良反应少,值得临床推广。
Objective To investigate the clinical efficacy of omeprazole in the treatment of peptic ulcer. Methods 2008-03-2010-07 60 patients with peptic ulcer treated in Kenli County People’s Hospital of Shandong Province were randomly divided into two groups, the treatment group and the control group of 30 cases, both groups were treated with amoxicillin 500 mg, 3 times / d. On the basis of this, the treatment group was given omeprazole 20 mg once a day, and the control group received ranitidine 150 mg once a day. The efficacy and adverse reactions of the two groups were compared. Results The healing rate of ulcer in treatment group was 93.3%, the total effective rate was 100%. The healing rate of ulcer in control group was 70.0% and the total effective rate was 86.7%. The two groups were statistically significant (P <0.01); both groups did not appear during the treatment of adverse reactions, medication safety. Conclusion Omeprazole treatment of peptic ulcer effect is significant, fewer adverse reactions, it is worth clinical promotion.