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孕鼠经腹腔一次性给予亚硝基乙基脲（ENU）可引起子代鼠中较高的脑肿瘤发生，并且与人类脑肿瘤发生的高峰期、类型及好发部位相似。建立该肿瘤模型其方法简便、经济、观察时间短，为肿瘤发生前、肿瘤发生早期及发生后不同阶段的观察提供了条件。经脑立体定向一次性颞叶实质内注射碱性成纤维细胞生长因子（b－FGF）其肿瘤内的新生血管面积和血管数既高于对照组肿瘤内，也高于同组瘤外正常组织内的新生血管面积和血管数。提示bFGF可以促进肿瘤内新生血管形成，也可能是影响肿瘤生长的原因。
Single intraperitoneal administration of nitrosyl ethylurea (ENU) to pregnant rats results in higher brain tumors in offspring rats and is similar to the peak, type and predilection sites of human brain tumors. The method of establishing the tumor model is simple, economical and short in observation time, which provides the conditions for the observation before the tumor occurrence and at the early stage and after the occurrence of the tumor. Intratumoral stereotactic temporal lobe parenchymal injection of basic fibroblast growth factor (b-FGF) within the tumor neovascularization area and blood vessels both higher than the control group tumors, but also higher than the same group of normal tissue outside the tumor Within the neovascularization area and the number of blood vessels. Tip bFGF can promote tumor angiogenesis, it may also affect tumor growth.