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目的 :观察剖宫产术后病人自控硬膜外镇痛 (PCEA)对催乳素 (PRL)、母乳量及婴儿体重的影响。方法 :选择 6 0例健康足月产妇 ,择期在硬膜外麻醉下施行剖宫产术。术毕随机等分为镇痛组和对照组。镇痛组行PCEA ,注入 0 2 %布比卡因 (2ml/h)持续 72小时镇痛。对照组术毕拔出硬膜外导管。两组采用放射免疫分析法测定血浆PRL。结果 :镇痛组VAS明显低于对照组 (P <0 0 1)。两组术后PRL较术前明显升高 (P <0 0 1) ,镇痛组术后PRL又显著高于对照组。镇痛组婴儿体重增加明显高于对照组 (P <0 0 5 ) ,肠蠕动恢复时间明显快于对照组 (P <0 0 1) ,镇痛组睡眠好。两组宫缩无显著性差异 (P >0 0 5 )。结论 :剖宫产术后布比卡因PCEA能促进PRL分泌 ,增加婴儿体重。
Objective: To observe the effects of PCEA on prolactin (PRL), breast milk and infant weight after cesarean section. Methods: Sixty healthy full-term pregnant women were selected. Elective cesarean section was performed under epidural anesthesia. The surgery was randomly divided into analgesia group and control group. Analgesia group PCEA, injection of 0.2% bupivacaine (2ml / h) for 72 hours analgesic. The control group was pulled out of the epidural catheter. Plasma PRL levels were measured by radioimmunoassay in both groups. Results: VAS in the analgesic group was significantly lower than that in the control group (P <0.01). The PRL in both groups was significantly higher than that before operation (P <0.01). The postoperative PRL in the analgesic group was significantly higher than that in the control group. Infant weight gain in the analgesic group was significantly higher than that in the control group (P <0.05), and the recovery time of intestinal peristalsis was significantly faster than that of the control group (P <0.01). No significant difference between the two groups of contractions (P> 0.05). CONCLUSION: Bupivacaine PCEA can promote PRL secretion and increase infant weight after cesarean section.