Anti-Cancer Effects of Novel Doxorubicin Prodrug PDOX in MCF-7 Breast Cancer Cells

来源 :华中科技大学学报：医学英德文版 | 被引量 : 0次 | 上传用户：wffgwffg

【摘要】

：

Ac-Phe-Lys-PABC-DOX(PDOX) is a smart doxorubicin(DOX) prodrug designed to decrease toxicities while maintaining the potent anticancer effects of DOX. This study

【作者】

：

张珏何良耿霞飞 Raymond A. Firestone

【机构】

：

DepartmentofOncology,NanjingMeihuaPharmaceuticals,HubeiKeyLaboratoryofTumorBiologicalBehaviors&,H

【出处】

：

华中科技大学学报：医学英德文版

【发表日期】

：

2014年4期

【关键词】

：

乳腺癌细胞抗癌作用前体药物阿霉素 MCF-7细胞 CASPASE 细胞毒性组织蛋白酶B breast cancer doxorubicin prod

【基金项目】

：

This project was supported by the grants from the Science Fund for Doctorate Mentors by Ministry of Education of China （No. 20120141110042）, New Strategies to Treat Peritoneal Carcinomatosis from Hube

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Ac-Phe-Lys-PABC-DOX(PDOX) is a smart doxorubicin(DOX) prodrug designed to decrease toxicities while maintaining the potent anticancer effects of DOX. This study was aimed at elucidating the effectiveness and toxicities of DOX and PDOX in patient-derived M

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Anti-Cancer Effects of Novel Doxorubicin Prodrug PDOX in MCF-7 Breast Cancer Cells

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