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过去认为白塞氏综合征极少发生肾脏损害,目前发现肾和其他组织一样常被累及。本文作者因发现1例合并蛋白尿(2g/24h)的白塞氏综合征患者,其肾脏呈现局灶性肾小球肾炎的病理改变,促使作者对另外10例同样患者进行了肾活检,并作光镜及免疫荧光检查。11例患者均为男性,年龄自25～42岁,病史自数月至15年,平均3年8个月。其中5例于行肾活检前曾接受强的松治疗,所有患者均无水肿及高血压等肾病征象。生化检查结果:5例尿蛋白定量大于0.1g/24h;6例尿中白细胞≥3/HPF;7例曾检测循环免疫复合物,其中6例阳性;血清肌酐水平均属正常。
In the past that Behcet’s syndrome rarely occurs kidney damage, and now found that kidney and other tissues are often involved. The authors of this study found that one of Behcet’s patients with albuminuria (2 g / 24 h) had a pathological appearance of focal glomerulonephritis in their kidneys, prompted the authors to perform renal biopsy on another 10 patients with the same patient For light microscopy and immunofluorescence. All 11 patients were male, aged from 25 to 42 years old, with a history of from 3 months to 15 years and an average of 3 years and 8 months. Among them, 5 patients received prednisone before renal biopsy, and none of them had signs of nephropathy such as edema and hypertension. Biochemical test results: 5 cases of urinary protein quantitation greater than 0.1g / 24h; 6 cases of urinary leukocytes ≥ 3 / HPF; 7 cases have been detected circulating immune complexes, of which 6 were positive; serum creatinine levels are normal.