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目的探讨单唾液酸神经节苷脂注射液在新生儿缺氧缺血性脑病治疗中的临床价值。方法选取64例新生儿缺血缺氧性脑病患儿,随机分为治疗组与对照组各32例。对照组给予基础治疗及脑蛋白水解物、胞二磷胆碱治疗,治疗组在对照组治疗基础上加用单唾液酸神经节苷脂20m静脉滴注治疗。观察两组神经行为测定(NBNA)评分、CT值、血清金属蛋白酶-9(MMP-9)水平。结果两组患儿治疗后较治疗前NBNA评分、CT值升高,MMP-9值下降,治疗前后比较差异有统计学意义(P<0.05);治疗前两组患者NBNA评分、CT值下降,MMP-9值比较差异无统计学意义(P>0.05),治疗后NBNA评分、MMP-9值两组组间比较差异有统计学意义(P<0.05);治疗1个疗程,对照组治疗总有效率为46.88%,治疗组总有效率为78.13%,两组比较差异有统计学意义(P<0.05)。结论新生儿缺血缺氧性脑病使用单唾液酸神经节苷脂治疗能明显减少MMP-9的释放,提高患儿治愈率,具有较高的临床治疗价值。
Objective To investigate the clinical value of monosialoganglioside injection in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods Sixty-four neonates with hypoxic-ischemic encephalopathy were randomly divided into treatment group (n = 32) and control group (n = 32). Control group was given basic treatment and brain protein hydrolyzate, citicoline treatment, the treatment group in the control group based on the treatment with monosialoganglioside 20m intravenous infusion. The NBNA score, CT value and serum MMP-9 level were observed. Results After treatment, NBNA score, CT value and MMP-9 value decreased significantly in both groups before and after treatment (P <0.05). NBNA score and CT value decreased in both groups before treatment, There was no significant difference in MMP-9 between the two groups (P> 0.05). After treatment, NBNA score and MMP-9 had statistical significance (P <0.05) The effective rate was 46.88%, the total effective rate was 78.13% in the treatment group, the difference between the two groups was statistically significant (P <0.05). Conclusion Neonatal hypoxic-ischemic encephalopathy using monosialoganglioside treatment can significantly reduce the release of MMP-9 and improve the cure rate in children with high clinical value.