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目的采用Meta分析系统定量地评价单纯补铁、铁和叶酸联合补充以及含铁的多种微量营养素补充对0～5岁儿童生长发育的影响,探讨铁在儿童生长发育中的作用,为儿童合理补铁提供科学依据。方法以“iron”、“folic acid”、“micronutrient”、“growth”、“growth and development”、“child”、“children”和“infant”为主题词和关键词联合检索PubMed、Medline、Embase、SinoMed、CNKI和万方数据库的相关文献,对符合纳入排除标准的文献进行质量评价及摘录所需数据,以年龄别身高(height for age z-score,HAZ)、年龄别体重(weight for age Z-score,WAZ)和身高别体重(weight for height Z-score,WHZ)干预前后变化值的标准均数差作为效应值,分为单纯补充、铁和叶酸联合补充以及含铁的多种微量营养素补充三部分,运用Revman5.2软件进行Meta分析。结果共纳入18篇合格文献。Meta分析显示,单纯补充铁对儿童HAZ影响的标准均数差(standard mean difference,SMD)=-0.07(95%CI:-0.32,0.18),对WAZ影响的SMD=0.05(95%CI:-0.03,0.13),对WHZ影响的SMD=0.09(95%CI:-0.06,0.25);铁和叶酸联合补充对儿童HAZ影响的SMD=0.46(95%CI:-0.06,0.99),对WAZ影响的SMD=0.18(95%CI:-0.00,0.37);含铁的多种微量营养素补充对儿童HAZ影响的SMD=0.40(95%CI:-0.13,0.92),对WAZ影响的SMD=0.25(95%CI:-0.08,0.59),对WHZ影响的SMD=0.01(95%CI:-0.15,0.16)。结论以10～30 mg/d的剂量补充铁对0～5岁儿童HAZ、WAZ和WHZ未起到促进作用。
Objective To quantitatively evaluate the effect of iron supplementation combined with iron and folic acid supplementation and iron supplementation on the growth and development of children aged 0 ~ 5 years using Meta analysis system, and to explore the role of iron in children’s growth and development, which is reasonable for children Iron supplements provide a scientific basis. The method starts with “iron ”, “folic acid ”, “micronutrient ”, “growth ”, “growth and development ”, “child ”, “children ” and “infant ”As the keywords and key words to search PubMed, Medline, Embase, SinoMed, CNKI and Wanfang database for the quality evaluation and excerpts of the documents that meet the exclusion criteria, with the height for age z-score (HAZ), weight for age Z-score (WAZ) and weight-height z-score (WHZ) Simple supplement, iron and folic acid combined with iron supplementation and micronutrient supplementation of three parts, the use of Revman5.2 Meta-analysis software. Results A total of 18 qualified documents were included. Meta-analysis showed that the standard mean difference (SMD) = -0.07 (95% CI: -0.32, 0.18) for SMD-supplementation with iron supplementation in children and the effect on WAZ were 0.05 (95% CI: 0.03,0.13), SMD = 0.09 (95% CI: -0.06,0.25) for WHZ effect; SMD = 0.46 (95% CI: -0.06,0.99) for effect of iron and folic acid supplementation on children HAZ, Of SMD = 0.18 (95% CI: -0.00, 0.37); SMD = 0.40 (95% CI: -0.13, 0.92) for the effect of micronutrient supplementation with iron on children’s HAZ; 95% CI: -0.08, 0.59), SMD = 0.01 for WHZ (95% CI: -0.15, 0.16). Conclusions Iron supplementation of 10 ~ 30 mg / d did not promote HAZ, WAZ and WHZ in children aged 0 ~ 5 years.