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1937年Vqiskott和1954年Aldrich先后描述一组血小板减少、湿疹和反复感染的X-链综合征,称为Wiskott-Adrich综合征(简称W-A综合征)。W-A综合征病人缺乏正常的细胞和体液免疫,易于患细菌、病毒和霉菌等感染。如不治疗,早期即可致死,但可用骨髓移植治疗。此类病人常患严重的单纯疱疹,如感染水痘,临床表现则较轻。目前尚无W-A综合征并发进行性水痘的报导。
In 1937 Vqiskott and 1954 Aldrich described a group of X-linked syndromes of thrombocytopenia, eczema and recurrent infections, known as Wiskott-Adrich syndrome (W-A syndrome). W-A syndrome patients lack normal cellular and humoral immunity and are susceptible to infections such as bacteria, viruses and molds. If not treated, early can be fatal, but can be treated with bone marrow transplantation. Such patients often suffer from severe herpes simplex, such as chickenpox infection, the clinical manifestations are lighter. There is no report of concurrent chickenpox with W-A syndrome.