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山楂Crataegus pinnatifida又名山里红,是一种在中国广泛分布的蔷薇科山楂属木本植物。山楂树(hawthorn tree)资源包括山楂浆果、山楂叶、山楂花、山楂树皮,富含黄酮类、三萜类、有机酸类、甾醇类及糖类等生物活性物质,均已被作为中药材应用于临床。目前国内外对山楂在临床防治糖尿病及其并发症方面进行了大量研究,发现山楂具有降血糖、调血脂、抗氧化应激、改善胰岛素抵抗、抗炎以及改善糖尿病并发的血管病变等作用。针对山楂树资源对2型糖尿病及其并发症的防治作用及其机制进行综述,为合理利用山楂资源及开发新型糖尿病治疗药物提供依据。
Hawthorn Crataegus pinnatifida, also known as the mountain red, is a widely distributed in China, Rosaceae hawthorn woody plants. Hawthorn tree resources include hawthorn berries, hawthorn leaves, hawthorn flowers, haw bark, flavonoids, triterpenoids, organic acids, sterols and sugars and other bioactive substances, have been used as Chinese herbal medicines Applied to clinical. At present, lots of researches have been done on the prevention and treatment of diabetes mellitus and its complications in hawthorn at home and abroad. It is found that hawthorn has the functions of lowering blood sugar, regulating blood fat, anti-oxidative stress, improving insulin resistance, anti-inflammation and improving the vascular lesion complicated by diabetes. In view of the effect of hawthorn resources on the prevention and treatment of type 2 diabetes mellitus and its complications and its mechanism, it provides a basis for rational use of hawthorn resources and the development of new type of diabetes therapeutic drugs.