论文部分内容阅读
目的分析新生儿抗生素相关性腹泻的原因及防治。方法选取医院儿科收治的新生儿316例作为研究对象,分为抗生素相关性腹泻(AAD)组和非AAD组,采取回顾性调查分析观察比较2组临床用药情况及相关指标。结果住院婴幼儿发生AAD 25例(7.91%)。AAD与患儿体质量低、年龄小、抗生素使用超过2种、应用3代头孢霉素、应用抗生素时间长、白细胞升高、C反应蛋白升高、合并重要脏器损害、住院时间长有关(P<0.01)。结论合理使用抗生素,尽量避免联合应用抗生素是控制住院新生儿发生AAD的关键。
Objective To analyze the causes and prevention of neonatal antibiotic-associated diarrhea. Methods A total of 316 newborns admitted to hospital for pediatric were enrolled in the study. The patients were divided into antibiotic-associated diarrhea (AAD) group and non-AAD group. Retrospective investigation and analysis were conducted to compare the clinical use of the two groups and related indicators. Results AAD occurred in 25 infants and young children (7.91%). AAD and children with low body mass, small age, the use of antibiotics more than 2, the application of 3 generations of cephalosporins, the application of antibiotics for a long time, leukocytosis, elevated C-reactive protein, combined with important organ damage, hospitalization for a long time P <0.01). Conclusion The rational use of antibiotics, try to avoid combined antibiotics is the key to control the occurrence of AAD in hospitalized newborns.