伊维菌素治疗盘尾丝虫病

• 作 者: 蔡银龙
• 出 处: 国外医学(寄生虫病分册)
• 发表日期: 1985年04期
• 关键词: 盘尾丝虫病 微丝蚴 皮肤活组织检查 丝虫 伊维菌素 低倍显微镜 寄生虫学 随访检查 眼前房 面部水肿

作者在巴黎进一步用伊维菌素(Ivermectin)单剂量口服治疗盘尾丝虫病12例,其中5例用150μg/kg,7例用200μg/kg。12例中9例有眼盘尾丝虫疾患。对所有病例,在治疗前进行了临床、眼科、寄生虫学及生物化学检查,治疗后住院的二周内又根据这些项目定期作了检查。皮肤微丝蚴密度,用皮肤活组织检查法测定。将样品置盐水中消化后,在低倍显微镜下检查微丝蚴并计数。在4周期间,微丝蚴密度下降到零。在仅有的一次随访检查中(第92天),12例中有1例查到微丝蚴。

In Paris, the authors further treated 12 cases of onchocerciasis with a single dose of Ivermectin, including 5 in 150 μg / kg and 7 in 200 μg / kg. Nine of 12 patients had ocular filarial disease. For all cases, clinical, ophthalmological, parasitic and biochemical tests were performed prior to treatment and were routinely checked on these items within two weeks after treatment. Skin microfilaria density, measured by skin biopsy. After digestion of the sample in saline, the microfilariae were examined under a low magnification microscope and counted. During 4 weeks, microfilaria density dropped to zero. In the only follow-up visit (day 92), microfilariae were detected in 1 out of 12 patients.