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本文通过复制犬急性血碳酸正常性代谢性酸中毒动物模型，动态观察动脉血和脑脊液（ＣＳＦ）酸碱变量。结果发现：Ⅰ组（脑室注射乙酰唑胺）［ＨＣＯ３］ＣＳＦ下降值同动脉血相似。Ⅱ组（脑室注射等量生理盐水）［ＨＣＯ３］ＣＳＦ以最小值下降。在两组［ＨＣＯ３］ａ下降值相似情况下，６ｈ水平Ⅰ组△［ＨＣＯ３］ＣＳＦ（１１．４ｍｍｏｌ／Ｌ）＞Ⅱ组△［ＨＣＯ３］ＣＳＦ（１．６ｍｍｏｌ／Ｌ，Ｐ＜０．０１）．说明乙酰唑胺能减少ＣＳＦＨＣＯ３的形成，ＣＳＦＨＣＯ３的形成与ＰＣＯ２和碳酸酐酶活性密切相关，ＨＣＯ３形成时产生的Ｈ＋部分由脑ＮＨ３缓冲。
In this paper, arterial and cerebrospinal fluid (CSF) acid-base variables were dynamically observed by replicating animal models of acute acidosis and acidosis in dogs. The results showed: Ⅰ group (intracerebroventricular injection of acetazolamide) [HCO3] CSF decline with arterial blood similar. Group Ⅱ (intraventricular injection of normal saline) [HCO3] CSF decreased with the minimum. The level of △ [HCO3] CSF (11.4mmol / L)> Ⅱ [HCO3] CSF (1.6mmol / L, P <0.01) . Acetazolamide can reduce the formation of CSFHCO3 formation, CSFHCO3 formation and PCO2 and carbonic anhydrase activity is closely related to the formation of HCO3 H + formed by the brain NH3 buffer.