论文部分内容阅读
目的:探讨缬沙坦联合大黄治疗糖尿病肾病的疗效。方法:早期糖尿病肾病(DN)患者61例和临床糖尿病肾病67例分别随机分为缬沙坦对照组和缬沙坦联合大黄治疗组,疗程均为6个月。结果:(1)与治疗前比较,治疗组治疗后血清总胆固醇(TC)、血清甘油三酯(TG)明显下降(P<0.05,P<0.01),血清高密度脂蛋白胆固醇(HDC-C)明显上升(P<0.05),对照组上述指标变化不明显(P>0.05)。(2)治疗后治疗组与对照组早期DN患者尿白蛋白(MA)、尿α1微球蛋白(α1-MG)、尿β2微球蛋白(β2-MG)均显著改善(P<0.05,P<0.01),而治疗组较对照组疗效显著(P<0.05)。(3)对临床DN患者的尿蛋白定量、尿α1-MG、尿β2-MG、血白蛋白(ALB)、血尿素氮(BUN)、血肌酐(Scr),治疗组均改善显著(P<0.05,P<0.01),且优于对照组,而对照组除尿蛋白定量、尿α1-MG、尿β2-MG改善显著(P<0.05)外,其余指标改善均不显著(P>0.05)。结论:缬沙坦联合大黄治疗DN疗效肯定。
Objective: To investigate the efficacy of valsartan combined with rhubarb in the treatment of diabetic nephropathy. Methods: Sixty-one patients with early diabetic nephropathy (DN) and 67 patients with clinical diabetic nephropathy were randomly divided into valsartan control group and valsartan combined with rhubarb treatment group for 6 months. Results: (1) Compared with those before treatment, serum total cholesterol (TC) and serum triglyceride (TG) in treatment group decreased significantly (P <0.05, P <0.01), serum HDL-C ) Was significantly increased (P <0.05), the control group did not change the above indicators (P> 0.05). (2) After treatment, urinary albumin (MA), urinary α1 microglobulin (α1-MG) and urinary β2 microglobulin (β2-MG) in patients with DN were significantly improved in treatment group and control group (P <0.05, P <0.01), while the treatment group than the control group significant effect (P <0.05). (3) Urine proteinuria, urinary α1-MG, urinary β2-MG, ALB, BUN, Scr in treatment group and treatment group all improved significantly (P < 0.05, P <0.01), and better than the control group, while the control group in addition to urinary protein, urinary α1-MG, urinary β2-MG improved significantly (P lt; . Conclusion: Valsartan rhubarb is effective in treating DN.