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目的:为了进一步研究EB病毒和鼻咽癌的关系,达到早期发现和早期治疗鼻咽癌的目的,我们在梧州市再次进行了鼻咽癌血清学检查,对象主要是30岁～39岁人群。并将结果和1980年我们对40～59岁人群的鼻咽癌普查结果进行比较。方法:抽取广西梧州市30～39岁正常人群的静脉血2ml,分离血清,于-20℃保存备用;用免疫酶法检测血清中VCA—IgA和EA-IgA;对VCA-IgA抗体阳性者进行临床检查,可疑者作活检及病理检查。结果:在16769人中,检出VCA-IgA阳性417人,EA-IgA阳性20人,鼻咽癌6例。鼻咽癌病人的VCA-IgA和EA-lgA均阳性,其几何平均滴度分别为1:113.1和1:28.3。检出的鼻咽癌病例全部为临床Ⅱ期。结论:鼻咽癌血清学普查对于早期发现鼻咽癌病人有着十分重要的作用。
OBJECTIVE: In order to further study the relationship between Epstein-Barr virus and nasopharyngeal carcinoma and achieve the purpose of early detection and early treatment of nasopharyngeal carcinoma, we carried out nasopharyngeal carcinoma serological examination again in Wuzhou City, mainly targeted at people aged 30 to 39 years old. The results were compared with our general survey of nasopharyngeal carcinoma in 40- 59-year-olds in 1980. Methods: 2ml venous blood was collected from 30-39-year-old normal people in Wuzhou, Guangxi. Serum was separated and stored at -20 ℃. VCA-IgA and EA-IgA were detected by enzyme immunoassay. VCA-IgA antibody positive Clinical examination, suspicious persons for biopsy and pathological examination. Results: In 16769 people, 417 VCA-IgA positive, 20 EA-IgA positive and 6 nasopharyngeal carcinoma were detected. VCA-IgA and EA-lgA were positive in patients with NPC, with geometric mean titers of 1: 113.1 and 1: 28.3, respectively. All cases of nasopharyngeal carcinoma were detected as stage Ⅱ. Conclusion: The serological survey of nasopharyngeal carcinoma plays an important role in the early detection of patients with nasopharyngeal carcinoma.