Studies on the Compounds of d4T Combined with Nitric Oxide Donors and Nitric Oxide Synthase Inhibito

• 作 者: KWALEMOLIMEGUITREMBIBlaise YAO
• 机 构: DepartmentofMedicinalChemistry
• 出 处: 南京医科大学学报：英文版
• 发表日期: 2004年2期
• 关键词: 一氧化氮 一氧化氮合成酶 人类免疫缺陷病毒 艾滋病 核苷类抗逆转录抑制剂 Stavudine (d4T) nitric oxide synthase (NOs)

Stavudine, a potent anti-HIV and AiDS-related complex, is one of the Nucleoside Analogue Reverse Transcriptase Inhibitors (NARTIs). It is phosphorylated intracellularly and then inhibits the viral reverse transcriptase by acting as a false substrate. Modi