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a-干扰素治疗仅对一部分慢性HBV感染的病人有效。治疗失败的原因还不清楚,但已知HBV的高度复制能抑制a-干扰素的免疫强化作用。为了研究病毒复制的完全抑制是否将增强干扰素诱导的对HBV的免疫反应,作者对单用a-干扰素治疗无应答的9例慢性乙型肝炎病人进行了研究。 这9例研究对象,HBSAg阳性至少12个月(男性,年龄:35.6±6.8岁),经过了一个全程的重组a-干扰素治疗(10Mu/次,3次
Interferon-alpha treatment is effective only in a subset of patients with chronic HBV infection. The cause of treatment failure is unclear, but it is known that a high degree of replication of HBV inhibits the immune enhancement of a-interferon. To investigate whether complete inhibition of viral replication would enhance the IFN-induced immune response to HBV, we conducted a study of 9 patients with chronic hepatitis B who did not respond to interferon-alpha alone. The 9 subjects were positive for HBSAg for at least 12 months (male, 35.6 ± 6.8 years of age) and underwent a full course of recombinant IFN-α therapy (10 MU / time, 3 times