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目的:观察早期应用丙种球蛋白治疗婴儿百日咳样综合征的临床疗效。方法:收集2011年1月至2016年1月收治的54例百日咳样综合征患儿的临床资料,随机分为治疗组和对照组,每组均为27例,两组患儿均给予大环内酯类抗生素抗感染、止咳化痰、雾化吸入等综合治疗,治疗组除综合治疗外,加用丙种球蛋白400mg·kg~(-1)·d~(-1),连用3~5d;对照组仅给予综合治疗,最后分析两组患儿的临床疗效。结果:治疗组婴儿的痉咳次数、痉咳时间、住院时间比对照组对比差异具有统计学意义(P<0.05)。结论:早期应用丙种球蛋白治疗婴儿百日咳样综合征疗效显著,降低治疗成本,减轻患儿痛苦,值得临床推广使用。
Objective: To observe the early clinical application of gamma globulin in the treatment of infant pertussis-like syndrome. Methods: The clinical data of 54 children with pertussis-like syndrome admitted from January 2011 to January 2016 were randomly divided into treatment group and control group, with 27 cases in each group. Both groups were given macrocyclic Lactone antibiotics anti-infective, cough and phlegm, inhalation and other comprehensive treatment, the treatment group in addition to comprehensive treatment, plus gamma globulin 400mg · kg ~ (-1) · d -1, once every 3 ~ 5d ; Control group only given comprehensive treatment, the final analysis of the clinical efficacy of two groups of children. Results: The frequency of spasmodic cough, spasmodic cough and hospital stay in treatment group were significantly different from those in control group (P <0.05). Conclusion: The early application of gamma globulin in the treatment of infant pertussis-like syndrome has obvious curative effect, reducing the treatment cost and alleviating the pain of children, which is worthy of clinical promotion.