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目的探讨分析丙型肝炎病毒感染与甲状腺疾病之间关系,为甲状腺疾病的预防提供有效参考。方法回顾性分析2003年1月—2014年1月在利辛县人民医院就诊的丙型肝炎病毒感染者642例,在治疗过程中发现感染者并发甲状腺疾病29例,收集所有慢性肝炎感染者一般性资料,并对所有可能潜在影响因素进行单因素和多因素分析。结果经分析发现,丙型肝炎病毒感染较其他类型肝炎病毒感染更容易引发甲状腺疾病,是诱发肝炎感染者出现甲状腺疾病的危险独立因素,之后对可能的单因素进行多因素Logistic回归分析,结果显示:干扰素疗程(OR=20.950,P=0.000)、性别(OR=6.716,P=0.000)以及负性情绪(OR=1.683,P=0.00)是丙型肝炎感染者诱发甲状腺疾病发生的危险因素。结论在治疗丙型肝炎感染者时,易诱发甲状腺相关疾病的发生,因此在治疗慢性肝炎感染者时,尤其是丙型肝炎感染者时,需要询问其甲状腺病史,定期对感染者的甲状腺相关指标进行检测,适当减少干扰素的使用疗程,并对感染者进行心理干预,定期复查,有效地防止丙型肝炎感染者甲状腺疾病并发症的发生。
Objective To investigate the relationship between hepatitis C virus infection and thyroid disease, and to provide an effective reference for the prevention of thyroid disease. Methods A retrospective analysis of 642 cases of hepatitis C virus infected patients in Lixin County People’s Hospital from January 2003 to January 2014 was conducted. During the treatment, 29 cases of thyroid diseases were found in those infected, and all those with chronic hepatitis were collected Sexual information and univariate and multivariate analysis of all possible potential influencing factors. Results The analysis showed that hepatitis C virus infection was more likely to cause thyroid disease than other types of hepatitis virus infection and was a risk independent factor for thyroid disease in patients with hepatitis infection. After that, multivariate Logistic regression analysis of possible single factors (OR = 20.950, P = 0.000), sex (OR = 6.716, P = 0.000) and negative emotions (OR = 1.683, P = 0.00) were the risk factors of thyroid disease in patients with hepatitis C . Conclusion In the treatment of hepatitis C infection, it is easy to induce the occurrence of thyroid-related diseases, so in the treatment of chronic hepatitis infection, especially hepatitis C infection, need to ask the history of thyroid, thyroid-related indicators of infection regularly Testing, appropriate to reduce the use of interferon treatment, and psychological intervention for infected persons, regular review, effectively prevent hepatitis C infection in patients with thyroid disease complications.