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低钾性周期性麻痹(hypokalemic periodic paralysis, HoPP)是以反复发作的骨骼肌弛缓性瘫痪为特征的一种疾病,发作时伴有血钾降低,有研究证实,本病与染色体1q31-32连锁DHPR的als亚单位突变引起的骨骼肌钙通道异常有关,在我国以散发者多见。以往对本病发生后血清肌酶的研究不多,认为血清肌酶升高是肌炎的重要特征,在HoPP不会出现血清肌酶的改变。为探讨两者之间的关系,我们1999-2003年对我科住院的38例HoPP病人进行血清酶学检查发现32 例病人血清肌酶升高,现报道如下。
Hypokalemic periodic paralysis (Hypokalemic periodic paralysis, HoPP) is a recurrent skeletal muscle flaccid paralysis characterized by a disease, accompanied by episodes of serum potassium decreased, studies have shown that the disease and the chromosome 1q31-32 chain DHPR als subunit mutation caused by skeletal muscle calcium channel abnormalities, more common in our country to disperse. In the past few studies on serum creatinine after the occurrence of this disease, that elevated serum creatinine is an important feature of myositis, HoPP will not appear in serum creatinine changes. To explore the relationship between the two, we in 1999-2003 hospitalized 38 cases of HoPP patients with serum enzymatic examination found that 32 patients with elevated serum creatinine, are reported below.