论文部分内容阅读
目的:用激活似然估计(Activation Likelihood Estimate)的Meta分析方法对慢性吸烟者的脑灰质变化情况进行分析和归纳。方法:首先,在Pub Med和Embase数据库中检索从2000年1月至2014年11月的基于体素的形态学分析方法(Voxel-based Morphometry)的慢性吸烟者灰质变化的研究,然后通过Ginger ALE软件包对所检索结果进行Meta分析和归纳。结果:检索得到528位慢性吸烟者和864例对照者的8篇研究。经过ALE分析可见,患者在右侧额中回(BA 10区)、右侧楔叶(BA 18区)、右侧扣带回前部(BA 32区)、左侧扣带回前部(BA 25区)、左侧额中回(BA 10区)、左侧额上回(BA 10区)和左侧岛叶(BA 13区)与健康对照组有显著差异。结论:我们的结果与前人运用信号差异图分析方法处理的结果类似,慢性吸烟者的额叶、岛叶、扣带回的灰质与对照组比较有显著差异,这一发现可加深我们对慢性吸烟者的脑结构改变的理解。
OBJECTIVE: To analyze and summarize the changes of gray matter in chronic smokers by the Meta-analysis of Activation Likelihood Estimate. Methods: Firstly, the changes of gray matter in chronic smokers who were based on Voxel-based morphometry from January 2000 to November 2014 were searched in the Pub Med and Embase databases. Then, the Ginger ALE The package performs a meta-analysis and generalization of the retrieved results. Results: Eight studies were retrieved from 528 chronic smokers and 864 controls. After ALE analysis, the patients were found on the right frontal gyrus (BA 10 zone), right wedge leaf (BA 18 zone), right cingulate gyrus (BA 32 zone), left cingulate gyrus (BA There was a significant difference between the left frontal gyrus (BA 10 zone), the left superior frontal gyrus (BA 10 zone) and the left insula (BA 13 zone) compared with the healthy controls. Conclusion: Our results are similar to the results of previous studies using signal difference graph analysis. Significant differences were found in the frontal lobe, insula, cingulate gray matter of chronic smokers compared with the control group. This finding may deepen our understanding of chronic Understanding of smoker’s brain structure changes.