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目的:探讨血清总胆汁酸测定在肝病诊断中的临床意义。方法:对280例肝病患者以及150例体检正常的成人血清TBA、ALtT、AST、r-3T的浓度进行对照比较。结果:肝病组患者血清中TBA浓度远远高于正常对照组,特别是急性黄疸型肝炎、原发性肝癌、肝硬化患者的血清总胆汁酸的异常率在83.3%以上。同时TBA在各种肝病的异常率高于常规肝功能检查。结论:TBA特异性高、敏感性尚可,测定TBA含量的变化,有助于各种肝病的诊断、病情变化的观察以及疗效和预后的判断。
Objective: To investigate the clinical significance of serum total bile acid in the diagnosis of liver disease. Methods: The serum concentrations of TBA, ALTT, AST and r-3T in 280 patients with liver disease and 150 healthy adults were compared. Results: Serum TBA concentration in patients with liver disease was much higher than that in normal controls, especially in patients with acute jaundice hepatitis, primary liver cancer and cirrhosis. The abnormal rate of serum total bile acid was above 83.3%. At the same time, the abnormal rate of TBA in various liver diseases is higher than that of routine liver function tests. Conclusion: TBA is highly specific and sensitive. The determination of the change of TBA content is helpful to the diagnosis of various liver diseases, the observation of the changes of the disease and the judgment of the curative effect and prognosis.