论文部分内容阅读
目的系统分析2011-2013年台州地区疑似预防接种异常反应(adverse event following immunization,AEFI)发生特征,评价预防接种服务的质量和疫苗的安全性。方法通过全国疑似预防接种异常反应监测系统按报告日期,收集台州市2011-2013年AEFI个案数据,采用描述性方法进行流行病学分析。结果 2011-2013年全市共报告532例AEFI病例;AEFI报告发生率为6.69/10万,一般反应估算发生率为4.83/10万,异常反应估算发生率为1.56/10万。一般反应以发热为主(75.2%),其次为红肿(43.49%)、硬结(17.19%);异常反应以过敏性皮疹为主(58.06%)。AEFI年龄≤1岁儿童为主,发生时间绝大多数在接种后0~1 d,AEFI发生报告率在10/10万以上的疫苗有7价肺炎、23价肺炎、乙脑灭活、流脑A+C结合、白破、HIB、麻风、水痘、无细胞百白破9种疫苗。结论疫苗预防接种异常反应报告发生率在预期范围内,所使用的疫苗安全性和服务质量良好。但个别疫苗的异常反应,需进一步动态观察。
Objective To systematically analyze the occurrence of suspected AEFI in Taizhou during 2011-2013 and evaluate the quality of vaccination services and vaccine safety. Methods Through the national monitoring system for suspected anaphylaxis immunization, the data of AEFI cases in Taizhou from 2011 to 2013 were collected according to the report date, and the descriptive method was used for epidemiological analysis. Results A total of 532 cases of AEFI were reported in the city from 2011 to 2013. The incidence of AEFI was 6.69 / 100 000, the incidence of general reaction was 4.83 / 100 000, and the incidence of abnormal reaction was 1.56 / 100 000. The general reaction was mainly fever (75.2%), followed by inflamed (43.49%) and induration (17.19%). The main reaction was allergic rash (58.06%). AEFI ≤ 1 year old children, the vast majority occurred in 0 ~ 1 d after inoculation, AEFI report rate of 10 million or more vaccines have pneumococcal pneumonia, 23 viremia, JE inactivation, meningitis A + C combination, white broken, HIB, leprosy, chickenpox, cell-free Dibahei 9 kinds of vaccines. Conclusion The incidence of abnormal vaccination report was within the expected range and the vaccine safety and quality of service used were good. However, the abnormal response of individual vaccines requires further dynamic observation.