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目的观察分析儿童造血干细胞移植前后的营养状态,并探究其与造血重建的关系。方法从2015年10月至2016年4月来我院接受初次造血干细胞移植的患儿中选出64例作为本次研究对象,测量所有患者在移植前后体质量、血清清蛋白和血清前白蛋白,并将患者根据移植前血清清蛋白是否低于正常水平分为2组:血清清蛋白低于正常水平为观察组,血清清蛋白是正常水平为对照组,比较2组患者造血重建情况,并进行分析评估。结果移植前所有患者的体质量、血清清蛋白和血清前白蛋白分别为(27.5±14.8)kg、(42.04±5.33)g/L、(187.62±54.9)g/L与移植后7、14、21 d相比差异有统计学意义(P<0.05)。观察组患者的白细胞植入时间和血小板植入时间分别为(17.61±5.84)d、(42.51±19.34)d,均明显长于对照组,差异有统计学意义(P<0.05)。结论患者在造血干细胞移植前存在营养不良,并且移植过程通过各种因素加大了营养不良的风险。通过改善患者的营养状态可促进患者的造血重建,缩短造血重建时间。
Objective To observe and analyze the nutritional status of children with hematopoietic stem cell transplantation before and after transplantation and to explore its relationship with hematopoietic reconstitution. Methods From October 2015 to April 2016 in our hospital to accept the first hematopoietic stem cell transplantation in children selected 64 cases as the object of this study, all patients before and after transplantation to measure body weight, serum albumin and serum prealbumin , And the patients were divided into two groups according to whether serum albumin before transplantation was lower than normal: serum albumin was lower than the normal level as the observation group, serum albumin was normal level as the control group, and the hematopoietic reconstitution was compared between the two groups For analysis and evaluation. Results The body mass, serum albumin and serum prealbumin in all patients before transplantation were (27.5 ± 14.8) kg, (42.04 ± 5.33) g / L, (187.62 ± 54.9) g / L and 7, 21 d compared with the difference was statistically significant (P <0.05). The leukocyte implantation time and platelet implantation time in the observation group were (17.61 ± 5.84) days and (42.51 ± 19.34) days, respectively, which were significantly longer than those in the control group (P <0.05). Conclusions Patients have malnutrition before hematopoietic stem cell transplantation and the transplant process increases the risk of malnutrition through a variety of factors. By improving the nutritional status of patients can promote the reconstruction of patients with hematopoietic and shorten the time of hematopoietic reconstruction.