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黏菌素被用于治疗多耐药革兰阴性菌引起的感染。甲磺酰黏菌素(colistin methanesulfonate,CMS)静脉滴注后能被水解为具活性的黏菌素。目前关于黏菌素的药动学资料还很有限。本文报道CMS和黏菌素在危重感染患者群体中的药动学特征。多重耐药革兰阴性杆菌(MDR-GNB)感染患者(排除
Colistin is used to treat infections caused by multi-drug resistant Gram-negative bacteria. Colistin methanesulfonate (CMS) can be hydrolyzed into active colistin after intravenous infusion. At present, the pharmacokinetics of colistin is still limited. This article reports the pharmacokinetic characteristics of CMS and colistin in critically ill patients. Patients with multidrug-resistant Gram-negative bacilli (MDR-GNB) (excluded