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药疹是最常见的药物不良反应,重症药疹常伴肾脏损害。药物肾损伤可分为四种临床类型:急性肾损伤、肾小球损伤、肾小管-间质损伤和肾石症/结晶尿。药物肾损伤是肾功能减退的常见病因,且经常被漏诊。临床工作中应仔细询问过敏史,严格掌握各种药物适应症。在用药过程中严密观察药物不良反应,一旦发现肾损伤,应及时停药或更换药物,同时促进药物排泄,保护肾功能,必要时应用糖皮质激素等,严重的肾功能衰竭患者应及时行肾脏替代治疗。
Drug eruptions are the most common adverse drug reactions, with severe drug eruption often accompanied by kidney damage. Drugs Kidney injury can be divided into four clinical types: acute kidney injury, glomerular injury, tubulointerstitial injury and nephrolithiasis / crystalline urine. Drug kidney damage is a common cause of renal dysfunction and is often missed. Clinical work should be carefully asked allergy history, strict control of various drug indications. In the course of medication closely observed adverse drug reactions, once found kidney damage, should be promptly discontinued or replaced drugs, while promoting drug excretion, protection of renal function, if necessary, the application of glucocorticoid, severe renal failure patients should promptly line the kidneys Alternative treatment.