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目的探讨佩尔地平对重度子痫前期患者的降压效果及妊娠结局的影响。方法选择经静脉给予佩尔地平治疗的重度子痫前期患者97例,分别记录用药前及用药后1、2、3、4、8、12、24h的血压、心率值,与妊娠结局相关的各项指标及药物不良反应。结果①与治疗前相比,给予佩尔地平治疗后患者收缩压与舒张压均显著下降(P<0.05),且24h内血压值控制平稳,而心率无明显改变。②使用佩尔地平治疗者保胎时间7d以上者19例(19.59%),Apgar评分1min评8分及以上者34例(35.05%),5min评8分及以上者73例(73.20%),新生儿体重(2605.98±784.79)kg,产后出血量为(207.58±62.90)ml。结论佩尔地平对重度子痫前期患者的降压效果显著、平稳,应用佩尔地平控制患者病情并适时终止妊娠对母儿预后有积极的作用。
Objective To investigate the effect of perdipine on the antihypertensive effect and pregnancy outcome in patients with severe preeclampsia. Methods Ninety patients with severe preeclampsia were treated with perdipine intravenously. The blood pressure and heart rate before treatment and 1,2,3,4,8,12,24h after treatment were recorded, Indicators and adverse drug reactions. Results Compared with those before treatment, the systolic and diastolic blood pressure of patients treated with perdipine were significantly decreased (P <0.05), and the blood pressure was controlled within 24 hours without any significant change in heart rate. (2) Perillodipine treatment in 19 patients (19.59%) with over 7d miscarriage time, 34 cases (35.05%) with 8 points or more in Apgar score 1 minute and 73 cases (73.20%) in 5 minutes score 8 and above, Neonatal body weight (2605.98 ± 784.79) kg, postpartum hemorrhage was (207.58 ± 62.90) ml. Conclusion Perlodipine has a significant and stable antihypertensive efficacy in patients with severe preeclampsia. Perlipid control of patients and timely termination of pregnancy have a positive effect on the prognosis of maternal and child.