论文部分内容阅读
目的:了解孕妇孕早期非遗传因素与先天性心脏病(CHD)之间的关系,为CHD病因防治提供线索。方法:收集2010年2月~2012年10月在深圳、郑州、福州和武汉4所三级医院产前诊断CHD胎儿的孕妇为病例组,采用1∶1配对病例对照研究,分析364对CHD胎儿的父母与对照组父母的非遗传暴露因素,对CHD可能的暴露因素进行风险评估。结果:怀孕前后遭遇负性生活事件(OR=2.161,95%CI:1.265~3.692)、孕早期感冒(OR=1.905,95%CI:1.197~3.032)及母亲家或单位附近有工厂(OR=1.825,95%CI:1.032~3.226)3个因素是后代发生CHD的危险因素,怀孕前后补充叶酸(OR=0.462,95%CI:0.265~0.805)及补充复合维生素(OR=0.432,95%CI:0.252~0.741)2个因素是后代发生CHD的保护因素。结论:母亲怀孕前后遭遇负性事件、孕早期感冒及母亲家或单位附近有工厂可能增加后代发生CHD的危险,而怀孕前后补充叶酸及复合维生素可能降低后代发生CHD的危险。
Objective: To understand the relationship between non-genetic factors and congenital heart disease (CHD) in pregnant women in early pregnancy and provide clues for the prevention and treatment of CHD. Methods: Pregnant women with prenatal diagnosis of CHD fetuses in 4 tertiary hospitals in Shenzhen, Zhengzhou, Fuzhou and Wuhan from February 2010 to October 2012 were selected as case group. A 1: 1 matched case-control study was conducted to analyze 364 pairs of CHD fetuses Parents and control group parents of non-genetic exposure factors, risk factors for possible exposure to CHD risk assessment. Results: Before and after pregnancy, there were negative life events (OR = 2.161,95% CI: 1.265-3.692), early pregnancy flu (OR = 1.905,95% CI: 1.197-3.032) and factories near the mother’s home or unit (OR = (OR = 0.462, 95% CI: 0.265-0.805) and supplementation with multivitamins (OR = 0.432, 95% CI: 1.825,95% CI: 1.032-3.226) were the risk factors of CHD in the offspring. : 0.252 ~ 0.741) Two factors are protective factors of CHD in the offspring. CONCLUSIONS: Maternal experiences of negative events before and after pregnancy, cold in early pregnancy and the presence of factories near the mother’s home or unit may increase the risk of CHD in offspring, while folic acid and multivitamins before and after pregnancy may reduce the risk of CHD in future generations.