论文部分内容阅读
目的探讨直肠神经内分泌瘤的临床病理特点、免疫组化、治疗方法及预后。方法分析30例直肠神经内分泌瘤患者的临床病理资料及HE切片,进行免疫组化染色并随访。结果 30例直肠神经内分泌瘤患者,组织结构表现为小巢状、梁状、腺泡状、混合型4种,免疫组化30例肿瘤Syn阳性29例(96.7%),Cg A阳性24例(80.0%),NSE阳性22例(73.3%),Ki67阳性3例(10.0%),CEA阳性2例(6.7%),CK20阳性5例(16.7%)。30例病例中直径≤1.0 cm 22例,1.1~2.0 cm 5例,>2.0 cm 3例,随访29例均存活。结论直肠神经内分泌瘤的诊断需要病理学检查及免疫组化,直肠神经内分泌瘤是低度恶性肿瘤,治疗取决于肿瘤大小,预后较好。
Objective To investigate the clinicopathological characteristics, immunohistochemistry, treatment and prognosis of rectal neuroendocrine tumors. Methods The clinical and pathological data of 30 patients with neuroendocrine neoplasms and HE slices were analyzed and immunohistochemically stained and followed up. Results Thirty patients with rectal neuroendocrine tumors showed four kinds of small nests, beams, alveoli and mixed type. The immunohistochemical results showed that Syn - positive in 29 cases (96.7%) and Cg A positive in 30 cases 80.0%), NSE positive in 22 cases (73.3%), Ki67 positive in 3 cases (10.0%), CEA positive in 2 cases (6.7%) and CK20 positive in 5 cases (16.7%). Of the 30 cases, 22 cases were ≤1.0 cm in diameter, 5 cases were 1.1-2.0 cm and> 2.0 cm. All 29 patients were followed up. Conclusion The diagnosis of rectal neuroendocrine tumors requires pathological examination and immunohistochemistry. Rectal neuroendocrine tumors are low-grade malignancies. The treatment depends on tumor size and the prognosis is good.