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真核细胞中含量最丰富的小G蛋白Ran(Ras relatednuclearprotein) ,具有与其所属的Ras家族其它成员不同的生化特点。其活性主要受到Ran的鸟苷酸交换因子 (RanGEF)RCC1(regulatorofchromosomecondensation 1) ,GTP酶激活蛋白 (GTPase activatingprotein ,GAP)以及Ran结合蛋白 (Ranbindingprotein ,RanBP)的调节。Ran主要参与了物质的核浆转运 ,此外在RNA出核、RNA合成、加工及细胞周期调控中也起到一定作用 ,并且是LPS活化基因的产物。
The most abundant R protein (Ras related nuclear protein) in eukaryotic cells has different biochemical characteristics than the other members of its Ras family. Its activity is mainly regulated by Ran of GCC regulator (RanGEF) RCC1 (regulator of chromosome condensation 1), GTPase activating protein (GAP) and Ran binding protein (RanBP). Ran is mainly involved in the nuclear transport of matter and plays a role in nuclear export, RNA synthesis, processing and cell cycle regulation, and is a product of LPS-activated genes.