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目的分析引起药物性肝病的药物种类、临床表现及预后,帮助临床医师早期诊断及及时治疗。方法回顾性分析62例药物性肝病患者的病因、临床表现及预后。结果致肝损害的主要药物以抗结核药物最常见,其次为非甾体消炎药物及抗菌药物。全部病例均有丙氨酸氨基转移酶(ALT)与天门冬氨酸氨基转移酶(AST)升高,多在复查时发现肝功能异常。除1例死于原发病并发症外,其余病例经停止使用或调整用药与使用保肝药物治疗后均获痊愈。结论药物性肝病可由各种药物引起,起病隐匿,临床详细的询问病史及肝功能检查是早期诊断的主要方法,早期及时停用肝损害药物并应用正确的保肝药物是治疗的关键。
Objective To analyze the types, clinical manifestations and prognosis of drug-induced liver disease, and to help clinicians to diagnose and treat them promptly. Methods Retrospective analysis of 62 patients with drug-induced liver disease etiology, clinical manifestations and prognosis. Results The main drugs causing liver damage were the most common anti-TB drugs, followed by non-steroidal anti-inflammatory drugs and anti-bacterial drugs. All patients had alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased, mostly in the review found that liver dysfunction. In addition to a case of primary complications of death, the remaining cases after stopping or adjusting medication and treatment with liver drugs were cured. Conclusion Drug-induced liver disease can be caused by a variety of drugs. The pathogenesis is insidious. Clinical history and liver function tests are the main methods of early diagnosis. Early and timely use of liver-damaging drugs and proper hepatoprotective drugs is the key to treatment.