论文部分内容阅读
真核细胞翻译起始因子4E(eukaryotic translation initiation factor4E,eIF4E)是与恶性肿瘤密切相关的因子之一,可与mRNA的5′端帽子结构特异性结合,在蛋白质合成的起始阶段发挥重要的调控作用。eIF4E的活性受自身磷酸化、翻译抑制蛋白的磷酸化及核内因子等因素的调节。eIF4E高表达于多种人类恶性肿瘤中,与肿瘤的发生、浸润和转移密切相关。目前已有一些以eIF4E为肿瘤治疗靶点的研究,如小分子干扰RNAs抑制eIF4E的表达、药物阻断AKT/mTOR或Raf/MEK/ERK信号通路、小分子抑制剂4EG1抑制帽依赖性翻译等,它们通过阻断eIF4E磷酸化抑制肿瘤细胞生长。总之,eIF4E有望成为恶性肿瘤生物治疗的新靶点。
Eukaryotic translation initiation factor 4E (eIF4E) is one of the closely related factors of malignant tumor, which can specifically bind to the 5 ’end of the mRNA and plays an important role in the initial stage of protein synthesis Regulation. The activity of eIF4E is regulated by factors such as autophosphorylation, translational repression of protein phosphorylation and nuclear factor. High expression of eIF4E in a variety of human malignancies, and tumorigenesis, invasion and metastasis are closely related. At present, there are some researches on the target of eIF4E for tumor therapy, such as the small interfering RNAs inhibiting the expression of eIF4E, the drugs blocking the AKT / mTOR or Raf / MEK / ERK signaling pathway, the small molecule inhibitor 4EG1 inhibiting cap-dependent translation , They inhibit tumor cell growth by blocking eIF4E phosphorylation. In conclusion, eIF4E is expected to become a new target for the biotherapy of malignant tumors.