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已知FK506因其与CyA(环孢素)作用相似可在肝肾移植中作为免疫抑制剂使用.实验采用细胞因子特异性单克隆抗体技术和间接免疫荧光法,观察在单细胞水平上FK506和CyA对单核因子和淋巴因子产生的抑制情况.其结果如下:在体外用有丝分裂
It is known that FK506 can be used as an immunosuppressive agent in liver and kidney transplantation because of its similar effect to CyA (cyclosporine) .In this study, cytokine-specific monoclonal antibody and indirect immunofluorescence were used to observe the effect of FK506 and CyA on mononuclear factor and lymphokine production inhibition.The results are as follows: In vitro with mitosis