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目的观察Tcu380A与MLcu375两种宫内节育器(intrauterine contraceptive device,IUD)的临床效果应用比较。方法2005年1月至2007年12月根据患者自愿并结合患者术时子宫情况采用对比性研究,为824例健康育龄妇女分别安置两种不同IUD。其中安置Tcu380A者420例,安置MLcu375者404例,对临床效果进行比较。结果两种IUD24个月的妊娠率、脱落率、因症取出率和续用率分别为Tcu380A:0.48%、0.48%、1.91%、95.7%,MLcu375:0.5%、5.2%、5.94%、86.38%。经统计学处理,两种IUD妊娠率比较无显著性差异(P>0.05);Tcu380A脱落率、因症取出率低于MLcu375(P<0.01);Tcu380A续用率高于MLcu375(P<0.01)。不良反应:Tcu380A异常出血率低于MLcu375(P<0.01);Tcu380A白带增多率低于MLcu375(P<0.05);腰腹痛发生率无明显性差异(P>0.05)。结论Tcu380A具有脱落率及因症取出率低,续用率高,不良反应少,是比较理想的IUD。
Objective To compare the clinical effects of two intrauterine contraceptive devices (TUD380A and MLcu375). Methods From January 2005 to December 2007, 824 healthy women of childbearing age were assigned to two different IUDs based on their voluntary combined with the patients’ uterus status. Among them, 420 cases were treated with Tcu380A, 404 cases were treated with MLcu375, and the clinical effects were compared. Results The pregnancy rate, exfoliation rate, symptom removal rate and recovery rate of Tcu380A were 0.48%, 0.48%, 1.91%, 95.7%, MLcu375: 0.5%, 5.2%, 5.94% and 86.38% . There was no significant difference in pregnancy rates between the two IUDs (P> 0.05). The rate of Tcu380A exfoliation was lower than that of MLcu375 (P <0.01), and the recovery rate of Tcu380A was higher than that of MLcu375 (P <0.01) . Adverse reactions: Tcu380A abnormal bleeding rate was lower than MLcu375 (P <0.01); Tcu380A vaginal discharge rate was lower than MLcu375 (P <0.05); no significant difference in the incidence of abdominal pain (P> 0.05). Conclusion Tcu380A has the advantages of low rate of abortion, high recovery rate and few adverse reactions. It is an ideal IUD.