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二麻降压冲剂单次灌胃给药对卒中型自发性高血压大鼠具有显著的降压作用,作用呈量效关系,降压高峰在给药后的3h～4h,降压作用可持续8h以上;连续灌胃给药2周对卒中型自发性高血压大鼠、肾动脉狭窄性高血压大鼠均具有显著的降压作用,作用呈量效关系,给药4d后达最大降压效应,此后血压稳定于该水平;连续灌胃给药6周对DOC盐性高血压大鼠具有持续稳定的降压作用,并不产生耐受性。对各种高血压模型动物在降压的同时心率均无明显加快。
A single intragastric administration of Erma Jiangyao Granule has a significant antihypertensive effect on stroke-induced spontaneous hypertensive rats, and the effect is dose-effect relationship. The antihypertensive effect can be sustained at the peak of blood pressure drop from 3h to 4h after administration. 8h or more; 2 weeks continuous administration of gavage has significant antihypertensive effect on stroke-induced spontaneous hypertensive rats and renal artery stenotic hypertensive rats in a dose-effect relationship, reaching the maximum blood pressure after 4 days of administration. The effect was that the blood pressure was stable at this level after that; administration of continuous gastric administration for 6 weeks had sustained and stable antihypertensive effect on DOC saline hypertensive rats, and did not produce tolerance. There was no significant increase in heart rate at the same time when blood pressure was reduced in various hypertension model animals.