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目的:探讨急性野生菌中毒合并器官功能损害患者血液净化治疗的临床疗效。方法:回顾我院2012年08月-2015年12月我科收治12例出现器官功能损害的急性野生菌中毒患者的临床资料进行回顾性分析。以上病例均于中毒入院后12小时内进行血液净化治疗;其中,7例接受血液透析滤过,3例血液灌流,2例进行血浆置换治疗;对12例患者治疗前后肝、肾功能、心肌酶及临床症状进行对比观察。结果:经治疗后,11例患者好转,临床症状明显改善,器官功能恢复,血尿素氮(BUN)、血肌酐(SCr)、肌酸激酶同工酶(CK-MB)、丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)明显下降,具有统计学意义(P<0.05)。1例患者因多器官功能衰竭死亡。结论:野生菌中毒的患者早期进行血液净化治疗结合常规药物治疗,能够提高患者的临床疗效,降低中毒患者死亡率。
Objective: To investigate the clinical efficacy of blood purification in patients with acute organism poisoning and organ dysfunction. Methods: The clinical data of 12 patients with acute organism poisoning who had organ dysfunction admitted in our hospital from August 2012 to December 2015 were retrospectively analyzed. All of the above cases were treated with blood purification within 12 hours after admission. Among them, 7 were hemodiafiltration, 3 were hemoperfusion and 2 were plasmapheresis. Before and after treatment, liver and kidney function, And clinical symptoms were compared. Results: After treatment, 11 patients improved, clinical symptoms improved significantly, organ function recovery, blood urea nitrogen (BUN), serum creatinine (SCr), creatine kinase CK, CK, alanine aminotransferase (ALT), aspartate aminotransferase (AST) decreased significantly, with statistical significance (P <0.05). One patient died of multiple organ failure. Conclusion: In the early stage, patients with wild-type bacteria poisoning can be treated with blood purification combined with routine drug therapy, which can improve the clinical efficacy and reduce the mortality of poisoned patients.