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脂质浸润学说认为动脉粥样硬化病变的发生是由于血浆中的脂质通过扩散作用,从血管内皮表面进入动脉内膜形成病变。病变的严重程度与血浆中某些脂质的浓度有关。因此一些导致血脂升高的因素,如膳食脂质过多等,也是脂质浸润或病变形成的必要条件。在进食高脂情况下遇应激时,血脂和动脉壁的改变如何?已知在应激时,体内儿茶酚胺分泌增加是由于交感神经兴奋的结果。由于儿茶酚胺分泌增加可能成为引起冠心病、心肌硬塞发生的内源性致病因素,因此我们通过给大白鼠进食高脂一个多月后,再向体内注射大量去甲肾上腺素以观察血脂和动脉壁的改变。 实验对象及方法:将PMC纯种大白鼠(182g～310g体重)随机分为两组。(1)正
The lipid infiltration theory states that the development of atherosclerotic lesions is due to the diffusion of lipids in plasma from the surface of the vascular endothelium into the arterial intima to form lesions. The severity of the lesion is related to the concentration of certain lipids in the plasma. Therefore, some factors that lead to elevated blood lipids, such as excessive dietary lipids, are also essential conditions for lipid infiltration or lesion formation. In the case of stress when eating high-fat diets, how are the changes in blood lipids and arterial walls? It is known that in stress, the increase in catecholamine secretion in the body is the result of sympathetic nerve activity. Since the increase of catecholamine secretion may be an endogenous pathogenic factor that causes coronary heart disease and myocardial infarction, we administered a large amount of norepinephrine to the body to observe blood lipids and arteries after feeding rats for more than one month. Wall changes. Experimental subjects and methods: PMC purebred rats (182g-310g body weight) were randomly divided into two groups. (1) Positive