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The synthesis of a new series of 3-(5-substituted benzimidazol-2-yl)-5-arylisoxazolines(6a-h) was achieved in excellent yields by the condensation of 1-(1H-benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones(5a-h) with hydroxylamine at room temperature.These 1-(1H-benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones(5a-h) were obtained by the condensation of 2-acetyl benzimidazoles(4a-d) with different aromatic aldehydes,which in turn were obtained by the oxidation of 2-(α-hydroxy) ethyl benzimidazoles(3a-d) prepared by the reaction of o-phenylenediamines(1a-d) withα-hydroxy propionic acid 2. The synthesized compounds were characterized by their IR,~1H NMR and MS analyses.These compounds were screened for their antibacterial and antifungal activity by standard methods and found some of them active.
The synthesis of a new series of 3- (5-substituted benzimidazol-2-yl) -5-arylisoxazolines (6a-h) was achieved in excellent yields by the condensation of 1- (1H-benzimidazol-2-yl) (substituted phenyl) prop-2-en-1-ones (5a-h) with hydroxylamine at room temperature.These 1- (1H-benzimidazol- 1-ones (5a-h) were obtained by the condensation of 2-acetyl benzimidazoles (4a-d) with different aromatic aldehydes, which in turn were obtained by the oxidation of 2- ) prepared by the reaction of o-phenylenediamines (1a-d) with α-hydroxy propionic acid 2. The compound compounds were characterized by their IR, ~ 1H NMR and MS analyzes. These compounds were screened for their antibacterial and antifungal activity by standard methods and found some of them active.