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当以重组鼠γ干扰素(γMuIFN-γ)于感染前和感染期间而不是仅在感染前给予小鼠,结果能增强小鼠对牛种布氏菌2 308感染的抵抗力。给小鼠γMuIFN-γ能增加腹膜和脾的巨噬细胞对牛种布氏菌的杀菌活性。用γMuIFN-γ加消炎痛治疗小鼠与仅用γyMuIFN-γ治疗后小鼠比较并不更能增强对感染的抵抗或巨噬细胞的杀菌活性。
When mice were administered with recombinant murine interferon (γMuIFN-γ) prior to and during infection rather than just before infection, the mice were able to increase their resistance to B. bovinus 28 308 infection. Mice γMuIFN-γ can increase the bactericidal activity of the peritoneum and spleen macrophages against B. bovinus. Treatment of mice with γMuIFN-γ plus indomethacin did not enhance the resistance to infection or the bactericidal activity of macrophages more than mice treated with γyMuIFN-γ alone.