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隆病毒(Torovirus)是动物胃肠炎的主要病原体之一,属于冠状病毒科,包括牛布里达病毒和马伯尔尼病毒。这是一种带包膜的RNA病毒,其颗粒呈球形或肾形,长100～140nm,中央隆起部是紧密卷曲的核衣壳。包膜刺突长约10nm。1984年第一次报道在人病毒性胃肠炎患者粪便标本中电镜检测到人类隆病毒颗粒,经抗原交叉反应和RNA分子杂交分析,证实这种人类隆病毒颗粒就是隆病毒。由于该病毒不能在细胞培养中生长,缺乏其他胃肠炎病毒的20面体对称结构,其包膜颗粒亦不如其他冠状病毒明显,因此有关研究较为有限。作者对1993年10
Torovirus is one of the major pathogens of gastroenteritis in animals and belongs to the family of Coronaviridae, including the Niri breed virus and the Marnellian virus. This is an enveloped RNA virus, the particles are spherical or kidney-shaped, long 100 ~ 140nm, the central bulge is tightly curled nucleocapsid. Envelope spikes about 10nm. In 1984, for the first time, human lung virus particles were detected by electron microscopy in human stool samples of patients with viral gastroenteritis. The antigenic cross-reactivity and RNA molecular hybridization analysis confirmed that this human squamous cell virus is a long virus. Since the virus can not grow in cell culture, the lack of other gastroenteritis 20 faceted symmetrical structure of the capsule particles nor other coronavirus obvious, so the study is more limited. The author of 1993 10