论文部分内容阅读
目的 :探讨肺部良恶性疾病患者手术前后血清IL - 10水平变化及临床意义。方法 :采用RIA法检测肺癌及肺部良性疾病患者手术前、手术后 1天、3天、7天、14天血清IL - 10水平 ,并与正常人进行比较。结果 :肺癌患者术前IL - 10水平明显高于术后 1天、3天、7天、正常人和手术前后良性疾病患者 ,具有非常显著性差异 (p <0 0 1) ,术后 1天、3天、7天与正常人比较无显著性差异 (p >0 0 5 ) ,术后 14天 36 4 %的肺癌患者IL- 10水平高于正常值上限。良性疾病患者手术前后无显著性差异。结论 :检测血清IL - 10水平是鉴别肺部良恶性疾病的一个较好参考指标 ,手术前后动态监测IL - 10水平变化对于观察肺癌患者病情变化、治疗效果具有一定临床意义。
Objective: To investigate the changes of serum IL - 10 level in patients with benign and malignant lung diseases before and after operation and its clinical significance. Methods: The serum levels of IL - 10 in patients with benign diseases of lung cancer and lungs before operation, 1 day, 3 days, 7 days and 14 days after operation were detected by RIA method and compared with normal subjects. Results: The preoperative IL - 10 level in patients with lung cancer was significantly higher than that of patients with benign disease at 1 day, 3 days and 7 days after operation. There was a significant difference (p <0.01) between normal subjects and patients with benign diseases before and after operation. One day after operation (P> 0.05). The level of IL-10 in 36 4% of lung cancer patients at 14 days after operation was higher than the upper limit of normal. There was no significant difference in benign disease patients before and after surgery. Conclusion: Detecting serum IL - 10 level is a good reference for differentiating benign and malignant lung diseases. The dynamic monitoring of IL - 10 level before and after operation is of clinical significance for the observation of the changes of lung cancer patients and the therapeutic effect.